The buffalo whey used to produce B-POWER’s concentrated whey proteins contains a unique variant of β-lactoglobulin, absent in cow’s whey.

This variant is rich in essential amino acids, particularly tyrosine, phenylalanine, valine, and leucine.

Leucine plays a key role in muscle protein synthesis and breakdown, and in stimulating insulin release from the pancreas. It is also easily digestible, resulting in small peptides with significant antioxidant activity.


1) Bassan, J.C., Goulart, A.J., Nasser, A.L.M., Bezerra, T.M.S., Garrido, S.S., Rustiguel, C.B., Guimarães, L.H.S., Monti, R. (2015) Buffalo Cheese Whey Proteins, Identification of a 24 kDa Protein and Characterization of Their Hydrolysates: In Vitro Gastrointestinal Digestion. PLoS ONE 10(10): e0139550

Sierolat’s R&D, in collaboration with Federico II and Vanvitelli Universities, identified δ-valerobetaine in buffalo whey as a powerful metabolite with multiple health benefits.

It shows antioxidant, anti-inflammatory, and antidiabetic effects, protecting cells from oxidative stress and hyperglycemia.

Research also highlights its anti-cancer potential, triggering apoptosis and necrosis in colorectal cancer cells by disrupting the cell cycle and selectively increasing ROS in tumor cells.

Non-intensive buffalo farming further boosts the natural presence of these beneficial compounds.

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Buffalo milk and whey contain GM1-class gangliosides at levels comparable to those found in human milk.

These bioactive compounds play a crucial role in modulating cellular signal transduction events, have demonstrated anti-inflammatory properties, and have shown promising results in clinical trials conducted on patients with Alzheimer’s disease.

1. Garau, V., Manis, C., Scano, P., Caboni, P. (2021) Compositional Characteristics of Mediterranean Buffalo Milk and Whey. Dairy, 2, 469–488

Buffalo milk is rich in oligosaccharides with immune-stimulating activity.

A rare pentasaccharide has been isolated from buffalo milk, showing structural similarities to human milk oligosaccharides and the ability to stimulate immune responses.

1. Saksena, R., Deepak, D., Khare, A., Sahai, R., Tripathi, L.M., Srivastava, V.M.L. (1999) A Novel Pentasaccharide from Immunostimulant Oligosaccharide Fraction of Buffalo Milk. Biochimica et Biophysica Acta 1428, 433-445